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Does Test Dose of Central Stimulant Influence Continuous Performance Test (CPT) and Activity in Boys with Attention Deficit Hyperactivity Disorder?

Background: Monitoring the effect of medication by using an objective measure would bring new perspectives to the work with patients suffering from Attention Deficit Hyperactivity Disorder (ADHD).

Objective: In order to objectify and monitor treatment efficiency, a Continuous Performance Test (the QB Test) was used and evaluated in daily clinical practice.

Method: A total of 12 boys aged 8-12 fulfilling diagnostic criteria for ADHD were tested using the QB Test before and after intake of methylphenidate.

Findings: One hour after intake of test dose of medicine, there were significant improvements on numbers of omissions (p=0.014), reaction time (p=0.038), correct responses (p=0.031) and activity (p=0.045). Nonsignificant improvements in reaction time variability (p=0.190) and correct non-responses (p=0.764) were found. Number of guesses and errors of commission were unchanged after medication.

Conclusions: The QB Test can be used to track effects of medication, showing greatest improvement in the most inattentive and hyperactive/impulsive children.


Merete Eybye Dam, Katrine Kaastrup Kolmos and Niels Bilenberg

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